Re: Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma. Editorial comment.

摘要

These authors used preoperative inflammatory response parameters to gauge the probability of long-term nonrecurrence in patients who underwent surgery for RCC. The association between the inflammatory response and malignant progression is poorly understood. My first memories of the association came from experiments revealing that in newly hatched chicks given injections of Rous sarcoma virus tumors developed at the injection site and despite virus in the blood no other tumors were found.1 However, when a wound was made away from the primary tumor, another tumor developed at the wound site. It was eventually found that wound tumor development correlated with circulating virus and inflammation, and in this case transforming growth factor-j8, and acidic and basic fibro-blast growth factor could replace wounding in tumor development.