wFeCl(3)-Catalyzed Intramolecular Michael Reaction of Styrenes for the Synthesis of Highly Substituted Indenes

摘要

An intramolecular FeCl3-catalyzed Michael addition reaction of styrene, a poor nudeophile, onto alpha,beta-unsaturated ketones was developed for the synthesis of highly substituted indene derivatives. The method was further applied to the total synthesis of the sesquiterpene natural products (+/-)-jungianol and 1-epi-jungianol.