Functional Characterizations of Effector Protein BipC, a Type III Secretion System Protein, in Burkholderia pseudomallei Pathogenesis

摘要

Objectives. The bsa locus of Burkholderia pseudomallei encodes several proteins that are components of the type III secretion system (TTSS). BipC was postulated as one of the TTSS-3 effector proteins, but its role in the pathogenesis of B. pseudomallei infection is not well understood. Thus, the aim of this study was to determine its role(s) in the virulence of B. pseudomallei pathogenesis.