One-pot multicomponent synthesis of highly substituted bicyclo[2.2.2]octane derivatives using bismuth nitrate as a catalyst

摘要

The one-pot synthesis of novel 3-(arylamino)-5,8-diaryl-1-hydroxy-N-2,N-6-diphenylbicyclo[2.2.2]oct-2-ene-2,6-dicarboxamides in good yields has been accomplished via the multicomponent reaction of aromatic aldehydes, substituted anilines, and acetoacetanilide using bismuth nitrate as a catalyst. (C) 2016 Elsevier Ltd. All rights reserved.