Stereoselective synthesis of cis-2,3-disubstituted indolines via an aza-alkylation/Michael cascade reaction

Yu Mirim; Kim Sung-Gon

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Stereoselective synthesis of cis-2,3-disubstituted indolines via an aza-alkylation/Michael cascade reaction

机译：通过氮杂烷基化/迈克尔级联反应立体选择性合成顺式2,3-二取代的二氢吲哚

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The stereoselective synthesis of cis-2,3-disubstituted indolines has been developed through an aza-alkylation/Michael cascade reaction of 2-(tosylamino)phenyl alpha,beta-unsaturated ketones with alpha-bromoacetophenone. This simple domino process afforded diverse highly functionalized indolines in high yields with good diastereoselectivities. (C) 2015 Elsevier Ltd. All rights reserved.

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2015年第50期|共4页
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Yu Mirim; Kim Sung-Gon;
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正文语种 eng
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Indoline; Cascade reaction; Michael addition; Aza-alkylation; Heterocycles;

机译：二氢吲哚;级联反应;迈克尔加成;氮杂烷基化;杂环;

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1. Stereoselective synthesis of cis-2,3-disubstituted indolines via an aza-alkylation/Michael cascade reaction [J] . Yu Mirim, Kim Sung-Gon Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2015,第50期

机译：通过氮杂烷基化/迈克尔级联反应立体选择性合成顺式2,3-二取代的二氢吲哚
2. The Mukaiyama-Michael Reaction of N-Acyl-2,3-dihydro-4-pyridones: Regio- and Stereoselective Synthesis of cis-2,6-Disubstituted 1,2,5,6-Tetrahydropyridines [J] . Jeffrey T. Kuethe, Daniel L. Comins Organic letters . 1999,第7期

机译：N-酰基-2,3-二氢-4-吡啶酮的Mukaiyama-Michael反应：顺式和2,6-二取代的1,2,5,6-四氢吡啶的区域和立体选择性合成
3. Stereoselective synthesis of tetracyclic indolines via gold-catalyzed cascade cyclization reactions [J] . Gianpiero Cera, Pasquale Crispino, Magda Monari, Chemical Communications . 2011,第27期

机译：通过金催化的级联环化反应立体选择性合成四环二氢吲哚
4. Diversity-Oriented Synthesis of 2,5-diketopiperazines via Ugi/6-Exo-Trig Aza-Michael Reaction Cascades in One Pot [C] . Tianyi Shang, Yan Pan, Zhong Chen International Conference on Advanced Composite Materials and Manufacturing Engineering . 2020

机译：通过UGI / 6-EXO-Trig AZA-Michael反应在一个锅中的多样性化合成2,5-二酮哌嗪
5. Part I. Synthesis of cytochrome P450-CAM substrate analogues towards developing cytochrome P450-CAM as an enzyme-based model system for mechanistic studies of important types of P450 reactions. Part II. Diels-Alder approach towards the synthesis of 2,3-disubstituted anthracene derivatives for luminescence spectroscopy characterization: Synthesis towards fluorescent sensors. [D] . Kemnitzer, William Edward. 1998

机译：第一部分。合成细胞色素P450-CAM底物类似物，以开发细胞色素P450-CAM作为一种基于酶的模型系统，用于重要类型P450反应的机理研究。第二部分Diels-Alder合成2,3-二取代蒽衍生物以进行发光光谱表征的方法：合成荧光传感器。
6. Stereoselective Synthesis of Dioxolanes and Oxazolidines via a Desymmetrization Acetalization/Michael Cascade [O] . David M. Rubush, Tomislav Rovis -1

机译：通过脱对称化/ Michael Cascade立体选择性合成二氧戊环和恶唑烷
7. Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions: Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes [O] . -1

机译：有机催化对映选择性级联迈克尔 - 烷基化反应：手性环丙烷的合成及其意外有机催化立体选择环环丙烷的调查

Stereoselective synthesis of cis-2,3-disubstituted indolines via an aza-alkylation/Michael cascade reaction

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