2,4,6-Trichloro-1,3,5-triazine and N,N '-dimethylformamide as an effective Vilsmeier-Haack reagent for the synthesis of 2-chloro-3-formyl quinolines from acetanilides

摘要

TCTA-DMF (2,4,6-trichloro-1,3,5-triazine/N,N'-dimethylformamide) adduct has been used as a Vilsmeier-Haack type reagent for effective synthesis of 2-chloro-3-formyl quinolines from acetanilides under conventional and ultrasonically assisted conditions. The reaction times under sonication are quite significantly shorter than conventional methods even though the yields obtained under sonication are comparable with those obtained under reflux conditions. (C) 2015 Elsevier Ltd. All rights reserved.