Use of the Bell-Evans-Polanyi Principle to predict regioselectivity of nucleophilic aromatic photosubstitution reactions

摘要

Regioselectivity of nucleophilic aromatic photosubstitution has been shown experimentally to depend upon activation energies of the competing transition states. Computational means of determining relative activation energies were sought, therefore, in order to predict regioselectivity. Optimization of the three triplet transition states of 2-chloro-4-nitroanisole with hydroxide ion gave energies of insufficient accuracy to predict regioselectivity. Computed enthalpy changes from the first triplet transition state to the triplet σ-complexes correlated precisely with the experimental activation energies. This exemplifies the Bell-Evans-Polanyi Principle, and it provides an accurate means of assessing regioselectivity.