Combining α-amidoalkylation reactions of iV-acyliminium ions with ring-dosing metathesis: access to versatile novel isoindolones spirocydic compounds

摘要

A novel approach to diversely spirocydic isoindoles iias been developed by using iV-acyliminium/ring-closing metathesis strategy. Spirocyclization precursors, diolefinic, and enyne spiro-fused-isoindole derivatives have been obtained by a regioselective reduction of the spiro-imide compounds, followed by the allylation of the N-acyliminium intermediates (generated from the acetoxylactam compounds). Ruthenium catalyzed ring-closing metathesis of the above unsaturated derivatives provided novel spiroisoindoles.