Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,l -b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-l-(6-phenylimidazo[2,l-b]thiazol-5-yl)ethanones and thioureas

摘要

N-Phenyl-4-(6-phenylimidazo[2,l-b]thiazol-5-yl)thiazol-2-amines (6a-q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-l-(6-phenylirnidazo[2,l-b]thiazol-5-yi)ethanones (4a-e) with suitably substituted thioureas using microwave heating. The ethanones (4a-e) were prepared by the reaction of 6-phenylimidazo[2,l-b]thiazoles (3a-e) with chloroacetylchloride in refluxing 1,4-dioxane whereas the thiazoles (3a-e) were synthesized by the reaction of 2-bromo-l-phenylethanones (2a-e) with thiazol-2-amine in refluxing acetone.