One-Pot Synthesis of Thiazoles via Hantzsch Thiazole Reaction and Their Antimicrobial Activity

摘要

In this work, substituted 2-bromo-1-phenylethanone compounds (1a-c) synthesized by reaction of bromine and various subtituted acetophenone. Compounds (1a-c) treated with thiosemicarbazide and several carbonyl species to gave corresponding substituted 4-phenyl-1,3-thiazole derivatives (2a-c to 6a-c) via multicomponent reaction and Hantzsch thiazole synthesis. All the synthesized compound tested for their antimicrobial activity.