Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo21-bthiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo21-bthiazol-5-yl)ethanones and thioureas

摘要

N-Phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines (>6a-q) have been synthesized by the Hantzsch thiazole reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones (>4a-e) with suitably substituted thioureas using microwave heating. The ethanones (>4a-e) were prepared by the reaction of 6-phenylimidazo[2,1-b]thiazoles (>3a-e) with chloroacetylchloride in refluxing 1,4-dioxane whereas the thiazoles (>3a-e) were synthesized by the reaction of 2-bromo-1-phenylethanones (>2a-e) with thiazol-2-amine in refluxing acetone.