An organocatalytic route to the synthesis of lactone moiety of compactin and mevinolin

Pradeep Kumar; Menaka Pandey; Priti Gupta

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An organocatalytic route to the synthesis of lactone moiety of compactin and mevinolin

机译：一种有机催化合成密实蛋白和美维诺林内酯部分的途径

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An efficient synthesis of lactone moiety of compactin has been achieved. The stereogenic centers were generated by means of iterative proline-catalyzed sequential α-aminoxylation and Horner-Wads-worth-Emmons (HWE) olefination of aldehydes.

机译：已经实现了密实蛋白内酯部分的有效合成。立体异构中心是通过迭代脯氨酸催化的顺序α-氨氧基化和醛的Horner-Wads-worth-Emmons（HWE）烯化反应生成的。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2010年第44期|共2页
作者
Pradeep Kumar; Menaka Pandey; Priti Gupta;
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正文语种 eng
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关键词
Lactone; Proline; Organocatalysis; Aminoxylation; Compactin;

机译：内酯;脯氨酸;有机催化;氨氧化;Compactin;

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1. An organocatalytic route to the synthesis of lactone moiety of compactin and mevinolin [J] . Pradeep Kumar, Menaka Pandey, Priti Gupta Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2010,第44期

机译：一种有机催化合成密实蛋白和美维诺林内酯部分的途径
2. Co-catalyzed two-stereocentered hydrolytic kinetic resolution: application to the synthesis of yashabushidiols A and B and the lactone unit of compactin and mevinolin [J] . Gadakh Sunita K., Sudalai Arumugam Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry . 2015,第2a3期

机译：共催化的两个立体中心的水解动力学拆分：在合成矢车菊二醇A和B以及紧密蛋白和美维林的内酯单元中的应用
3. Enantioselective Synthesis of (+)-(S)-7,8-Dihydrokavain and (4R,6R)-4-Hydroxy-6-(2-phenylethyl)tetrahydro- 2H-pyran-2-one, Lactone Analog of Compactin and Mevinolin [J] . I. V. Mineeva Russian Journal of Organic Chemistry . 2013,第5期

机译：（+）-（S）-7,8-二氢卡哇因和（4R，6R）-4-羟基-6-（2-苯乙基）四氢-2H-吡喃-2-酮，内酯类固醇和美维宁的对映选择性合成
4. Liposomal camptothecin with impproved lactone-moiety stability and enhanced antitumor activity [C] . G. Chen, L. Gong, B. C. Giovanella, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：脂质体喜树碱具有改善的内酯部分稳定性和增强的抗肿瘤活性
5. Synthesis of Novel Polymer Materials via Organocatalytic Ring-Opening Polymerization (ROP) of Cyclic Lactones [D] . Inush Kalana, U.L.D. 2021

机译：通过环状内酯的有机催化开环聚合（ROP）合成新型聚合物材料
6. Biosynthesis of the pyrimidine moiety of thiamine. A new route of pyrimidine biosynthesis involving purine intermediates [O] . P. C. Newell, R. G. Tucker 1968

机译：硫胺素嘧啶部分的生物合成。嘧啶中间体合成嘧啶的新途径
7. A versatile kinetic alkylation-ozonolysis route for the synthesis of lactones: chiral γ-lactones and racemic δ-lactones [O] . Niall W.A. Geraghty, Declan P. Costello 2003

机译：用于合成内酯的通用动力学烷基化 - 臭氧分解途径：手性γ-内酯和外消旋δ-内酯

An organocatalytic route to the synthesis of lactone moiety of compactin and mevinolin

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