The first stereoselective total synthesis of (3S,4R)-dihydroxy-(6S)-undecyl-α-pyranone and total synthesis of (2S,3K,5S)-(-)-2,3-dihydroxytetradecan-5-olide

摘要

The first total synthesis of (3S,4R)-dihydroxy-(6S)-undecyl-α-pyranone 1 and total synthesis of (2S,3R,5S)-(-)-2,3-dihydroxytetradecan-5-olide 2 have been achieved in five steps in a highly stereoselective manner using Maruoka aliylation, olefin cross-metathesis, and Sharpless asymmetric dihydroxylation as key steps.