Peptides comprising a (1S,2R,3R)- or (1R,2S,3S)-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptane or -hept-5-ene residue useful in the total synthesis of cyclosporins, and processes for their production

摘要

Novel [1S, 2R, 3R]- and [1R, 2S, 3S)-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes. Such compounds are useful in the total synthesis of cyclosporins, in particular cyclosporin A, e.g. applying the method described and claimed in co-pending European Patent Application No. 81 810 043.0.