Synthetic studies on the taxane skeleton:effective construction of eight-membered carbocyclic ring by palladium-catalyzed intramolecular alpha-alkenylation of a methyl ketone

摘要

A new method for the construction of the eight-membered carbocyclic ring in the taxane skeleton is described.The palladium-catalyzed intramolecular a-alkenylation of a methyl ketone effectively constructed the eight-membered carbocyclic ring in the taxol model compound.To the best of our knowledge,this reaction is the first example of forming an eight-membered carbocyclic ring by the palladium-catalyzed intramolecular alpha-alkenylation of a ketone.