The synthesis of new,selected analogues of the pro-apoptotic and anticancer molecule HA 14-1

摘要

A new and versatile strategy has been developed towards HA 14-1 analogues,selectively modified on position 4 and/or on the primary amine function.An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde,allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2'.