Stereoselective synthesis of belactosin C and its derivatives using a catalytic proline catalyzed crossed-aldol reaction

摘要

A highly practical and concise stereoselective total synthesis of belactosin C and synthetic variants was achieved using an S-proline catalyzed crossed-aldol reaction as the key step.Many natural products possessing the 2-oxetanone (beta-lactone) moiety exhibit biological activity such as antibiotic,antitumour and antiobesity.Prominent natural molecules bearing a 2-oxetanone ring include anisatin,a potent vegetal poison and the antibiotic 1233A.