Transfer allyl esters to thioesters in solid phase condition: synthesis of peptide thioesters by Fmoc chemistry

摘要

A method to transfer allyl esters to thioesters under a solid phase condition has been developed to synthesize peptide thioesters.A Fmoc chemistry has been applied to synthesize the peptide allyl esters,which are selectively transferred to the expected peptide thioesters under solid phase synthesis conditions successfully.