The first example of samarium diiodide-promoted intramolecular ketone-ester coupling of ketones tethering acyloxyalkyl side chains producing 2-hydroxy cyclic hemiacetals

摘要

The reaction of samarium diiodide with some cyclic and acyclic ketones tethering acyloxyalkyl side chains produced 2-hydroxy cyclic hemiacetals in moderate to good yields,in which an intramolecular addition of samarium ketyl radicals to distant ester carbonyls would be involved.