Aglycon switch approach toward unnatural glycosides from natural glycoside with glycosyltransferase VinC

摘要

New aglycon switch approach using glycosyltransferase VinC was explored to create unnatural glycosides from natural glycoside in one-pot reaction. This aglycon switch comprises from two reactions, where NDP-vicenisamine generated in situ from natural glycoside vicenistatin and NDP by the reverse reaction is transferred to the targeted additional aglycons to form unnatural vicenisaminides by the forward reaction. (c) 2005 Elsevier Ltd. All rights reserved.