A convenient solid phase synthesis of S-palmitoyl transmembrane peptides

摘要

S-Palmitoylated peptides are important tools as models for integral membrane proteins to study peptide-lipid interactions.Herein,we report a convenient solid phase synthesis of S-palmitoyl transmembrane peptides.The highly acid labile S-(4-meth-oxytrityl) group is preferred over the S-(tert-butylsulfanyl) group for protection of the cysteine side chain since the latter gives rise to quantitative desulfurization during on-resin deprotection.The resulting free thiol function is modified with palmitic acid via a carbo-diimide-mediated coupling and the title compounds are obtained in good yields and purity.