Synthesis of chiral nonracemic polyimine macrocycles from cyclocondensation reactions of biaryl and terphenyl aromatic dicarboxaldehydes and 1R,2R-diaminocyclohexane

摘要

The synthesis of biaryl and terphenyl dicarboxaldehydes using Suzuki coupling methodology and their macrocyclisation reactions with 1R,2R-diaminocyclohexane yielding novel polyimine macrocycles derived from the [2+2] and [3+3] cyclocondensation reactions is presented.The ratio of products was found to depend on the overall geometry of the dicarboxaldehydes.