Efficient synthesis of RGD-containing cyclic peptide-porphyrin conjugates by ring-closing metathesis on solid support

摘要

We report the efficient solid-phase synthesis of a new family of peptidic porphyrins containing a constrained RGD moiety obtained by ring-closing metathesis.Photodynamic therapy (PDT) is a new method for the treatment of cancer that has received considerable attention in recent years.