Access to enantiopure polycyclic beta-lactams by Diels-Alder reaction of novel inner-outer-ring 2-(silyloxy)dienes with a carbacepham skeleton

摘要

The synthesis of unprecedented inner-outer-ring 2-[tert-butyldimethylsilyloxy]dienes with a carbacepham structure in optically pure form and their totally pi-facial endo selective Diels-Alder reactions to structurally novel polycyclic P-lactams is reported.