Palladium-catalyzed borylation and Suzuki coupling (BSC) to obtain β-substituted dehydroamino acid derivatives

摘要

Several benzo[b]thienyldehydroamino acids were prepared by one-pot palladium-catalyzed borylation and Suzuki coupling (BSC) from bromobenzo[b]thiophenes containing EDG (OMe or Me), as the component to be borylated with pinacolborane, and pure stereoisomers of β-bromodehydroamino acid derivatives. To our knowledge it is the first time that the BSC reaction involves a non aromatic system.