PROCESS FOR THE PREPARATION OF 2-(METHOXY-IMINO)-2-ARYL-ACETIC ESTER DERIVATIVES VIA PALLADIUM-CATALYZED CROSS COUPLING REACTION, BORON ACIDES INTERMEDIATES THEREOF AND USE OF THE LATTER

摘要

PCT No. PCT/EP95/00146 Sec. 371 Date Jul. 22, 1996 Sec. 102(e) Date Jul. 22, 1996 PCT Filed Jan. 16, 1995 PCT Pub. No. WO95/20569 PCT Pub. Date Aug. 3, 1995Process for the preparation of 2-methoxyimino-2-arylacetic esters of formula (I) in which R is C1-C12alkyl, which comprises reacting an appropriately substituted boronic acid of general formula (II) or the trimeric form (lII) herein, which is in equilibrium with it, in the presence of a Pd catalyst, with a methoxyiminoacetic ester of formula (IV) in which R is C1-C12alkyl and X is a leaving group. According to a further process variant, in principle the groups which split off the two reactants may change places. The process can be applied not only to phenyl derivatives but also to larger ring systems (naphthyl, pyridyl, heterocycles).