Expanded applicability of iridium(I) NHC/phosphine catalysts in hydrogen isotope exchange processes with pharmaceutically-relevant heterocycles

摘要

An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged. Substrate scope, competition experiments and labelling of drug type molecules have revealed PR3=PPh3 provides a broadly more applicable and widely effective catalyst system compared to other available complexes in the present series. (C) 2015 Elsevier Ltd. All rights reserved.