In a patient with a primary Gleason score (GS) pattern of 3, our policy is to attribute the secondary GS to the worse pattern detectable, independently from its extent, rather than assigning a tertiary pattern. So, definitely, in our study, all the patients with an insignificant prostate cancer (ins-PCa) had a pure GS 3+3. Thus, why insignificant and significant PCa patients showed similar recurrence rates is not clear, also considering that positive surgical margins were lower for the former (6.4% vs 37.2%, P <.001) and that lymphadenectomy was done in a similar number of patients (65.3% vs 68.9%, P not significant). The reason probably relies only on the small number of events of relapse that occurred, which could have undermined the power of this statistical comparison.
展开▼
