Copper-catalyzed oxidative trifluoromethylation of terminal alkenes using nucleophilic CF _3SiMe _3: Efficient C(sp ~3)-CF _3 bond formation

摘要

An efficient C(sp ~3)-CF _3 bond-forming reaction via Cu-catalyzed oxidative trifluoromethylation of terminal alkenes has been developed, which proceeds under mild conditions using readily available, less expensive CF _3SiMe _3 as the source of the CF _3 group. This method allows access to a variety of trifluoromethylated allylic compounds.