Ultrasound-Triggered Smart Drug Release from Multifunctional Core?Shell Capsules One-Step Fabricated by Coaxial Electrospray Method

摘要

Multifunctional core?shell capsules that triggered release by ultrasound stimulus were one-step fabricated by the coaxial electrospray method. The TiO_2 shell suppressed the initial burst release of the paclitaxel. Fe_3O_4 and graphene quantum dots inside the oil core functioned successfully for magnetic targeting and fluorescence imaging, respectively. Paclitaxel was trigger released when the dual layer of titania shell cracked under the ultrasound stimulation, and the releasing profile could be controlled by the length of applied ultrasound time.