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Pre-fabricated semi-permeable capsule shells containing a semipermeable layer on a water-dispersible/soluble gelatinous shell for osmotic drug delivery system
Pre-fabricated semi-permeable capsule shells containing a semipermeable layer on a water-dispersible/soluble gelatinous shell for osmotic drug delivery system
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机译:预制的半透性胶囊壳,在水分散性/可溶性胶状壳上含有半透层,用于渗透性药物递送系统
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摘要
The present invention is centered on the design, manufacturing and use of a novel capsule system made up of a bi- or multi-layered two piece capsule shell made of a water soluble/dispersible layer coated with water-insoluble semi-permeable membrane capsule shell. The therapeutic agent is formulated in the drug layer and the osmotic layer is compacted together. The osmotic layer is a rate controlling agent. This compacted core is then inserted in the body of the layered body followed by encapping with a layered cap (which is pre-drilled or drilled after inserting the core) followed by applying a sealing agent as a band where the body and the cap of capsule meet.
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