Dose-dependent effect of isoflurane on regional cerebral blood flow in anesthetized macaque monkeys

摘要

The dose-dependent effect of isoflurane on regional CBF of cortical and subcortical structures in anesthetized macaque monkeys was investigated with the Continuous ASL MRI technique. High concentration of isoflurane resulted in global CBF increase and blood pressure decrease. Evident CBF change was observed in the subcortical structures. Specifically, CBF in thalamus and cerebellum was increased about 39% and 55% when isoflurane concentration was changed from 0.75% to 1.5%, respectively. Also, those regional CBF changes correlated linearly with isoflurane inspiratory concentrations, indicating impaired CBF autoregulation in these structures. In contrast, no obvious CBF changes were observed in anterior cingulated cortex, motor cortex, medial prefrontal cortex, and caudate. The results demonstrate that, under the 0.75-1.5% isoflurane maintenance doses, the CBF auto-regulation is well preserved in the cerebral cortical regions and caudate, but impaired in thalamus and cerebellum, indicating disturbed CBF-metabolism coupling and functional response in specific subcortical regions of anesthetized macaque monkeys.