Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells

摘要

Stem cells are functionally defined through their replicative capacity [26,30] and ability to generate diverse differentiated cells [2,22,31]. Somatic stem cells can provide properly differentiated cells to restore the function of tissues in the human body damaged by several factors, including reactive oxygen species (ROS) production, inflammation, ischemia, apoptosis, and physical damage. As unhealthy or older people often fail to replace their damaged cells due to functional weakness at their stem cells [3,5,29], stem cell therapies are an attractive option. The usage of unhealthy stem cells could give a weak therapeutic efficacy in patients; therefore, autologous stem cells need to be improved prior to applications in cell therapy.