Preconditioning with hypercapnic acidosis: Hope for the ischemic brain

摘要

Acidosis is an important stress factor triggering cell death under ischemic stress. Accordingly, short acidic pretreatment, . i.e. acidic preconditioning, has been used to protect heart and liver. Now the beneficial effect of pretreatment with hypercapnic acidosis against ischemia/reperfusion-induced cell death has also been shown for the brain. The possible underlying cellular mechanisms of the protection as well as role of acidic and hypercapnic sensing are briefly discussed.