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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Inter-individual difference in pupil size correlates to suppression of melatonin by exposure to light.
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Inter-individual difference in pupil size correlates to suppression of melatonin by exposure to light.

机译:个体之间瞳孔大小的差异与通过暴露于褪黑激素的抑制有关。

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摘要

There are large inter-individual differences in pupil size and suppression of melatonin by exposure to light. It has been reported that melatonin suppression by exposure to light increases when pupils are pharmacologically dilated. However, the correlation between normal inter-individual difference in pupil size and melatonin suppression by exposure to light is not clear. Twenty-three healthy male subjects (22.6+/-2.7 years old) were exposed to light (1000 lx) for 2 h at night. The starting time of exposure to light was set to the ascending phase of melatonin concentration of each subject. Pupil area and saliva melatonin concentration were measured before exposure to light under dim light (15 lx) and during exposure to light. There were large inter-individual differences in melatonin suppression and pupil area. The mean and standard deviation of percentage of melatonin suppression 2 h after exposure to light was 57.2+/-22.1%. The mean and standard deviation of pupil areas before and 2 h after exposure to light were 30.7+/-7.9 mm2 and 15.9+/-4.8 mm2, respectively. The percentage of melatonin suppression by light was positively correlated with pupil area during light exposure (r=0.525, p0.02). Interestingly, it was also correlated with pupil area measured before exposure to light, under dim light (15 lx) (r=0.658, p0.001). These results suggest that inter-individual difference in pupil area positively correlates with melatonin suppression by light and that pupil area under dim light is a predictor of inter-individual differences in melatonin suppression by light.
机译:个体之间在瞳孔大小和暴露于褪黑素的抑制作用方面存在很大的个体差异。据报道,当瞳孔在药理学上扩张时,通过暴露于褪黑激素会增加抑制作用。但是,瞳孔大小的正常个体差异与曝光后褪黑激素抑制之间的相关性尚不清楚。 23名健康的男性受试者(22.6 +/- 2.7岁)在夜间(1000 lx)暴露2 h。曝光的开始时间设置为每个受试者的褪黑激素浓度的上升阶段。在昏暗的光线(15 lx)下曝光之前和曝光期间,测量瞳孔面积和唾液褪黑激素浓度。褪黑素抑制和瞳孔面积在个体间差异很大。曝光后2 h褪黑素抑制百分比的平均值和标准偏差为57.2 +/- 22.1%。曝光前和曝光后2小时的瞳孔面积的平均偏差和标准偏差分别为30.7 +/- 7.9 mm2和15.9 +/- 4.8 mm2。光照过程中褪黑激素的抑制百分比与瞳孔面积呈正相关(r = 0.525,p <0.02)。有趣的是,它也与在昏暗的光线(15 lx)下曝光前测得的瞳孔面积相关(r = 0.658,p <0.001)。这些结果表明,瞳孔面积的个体差异与光抑制褪黑素正相关,而暗光下的瞳孔面积是光抑制褪黑素个体差异的预测因子。

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