Synthesis of beta-Trifluoromethylated Ketones from Propargylic Alcohols by Visible Light Photoredox Catalysis

摘要

Regioselective trifluoromethylation at a remote position represents an important challenge in the development of biologically active molecules and functional materials. A practical method to access -trifluoromethyl ketones from readily available propargylic alcohols by visible light photocatalysis has been developed. Trifluoromethylation of propargylic alcohols with CF3I in the presence of Ru(bpy)(3)Cl-2 as the photocatalyst followed by double-bond migration/keto-enol tautomerization provides -trifluoromethyl ketones as the final product.