- Prepartion method for trifluoromethyl substituted heterocycles via visible light photoredox catalysis

摘要

The invention heterocycle and methyl iodide in the presence of a mixture of trifluoroacetic ruthenium photocatalyst reacting the carbon of the heterocycle by a visible light - methyl hydrogen bonding trifluoroacetic substituting trifluoromethyl - relates to a method for producing a substituted heterocycle , when the introduction of a methyl group to a compound that trifluoroacetate metabolic stability of the compound , lipid solubility , it is possible to bioavailability , such as the activity of the binding selectivity changes , trifluoromethyl- prepared or in pharmaceutical and organic synthesis of chemicals , including substituted heterocycle can be widely utilized . ;