Author response: Passing-Bablok regression is inappropriate for assessing association between structure and function

摘要

We thank Marin-Franch1 for his comments on our recent paper.2 If some aspects of the statistical analysis were not as clear as they perhaps could have been, we are grateful for the opportunity to address them here. The first concern was that our conclusion was in conflict with previous findings.3,4 Hood et al.3 assumed that there is no relationship between retinal nerve fiber layer thickness and visual field sensitivity in healthy observers; this was not a finding, but a working assumption. This point was made in our paper. On the other hand, Wollstein et al.4 suggested that substantial structural loss must occur in the retina before functional damage can be detected using current testing methods; however, other published data support the notion that retinal structure and visual function are associated in healthy eyes.5,6