Clindamycin Phosphate 1.2% and Benzoyl Peroxide 2.5%: A New, Once-Daily, Fixed Combination Treatment for Moderate to Severe Acne

摘要

Fixed combination products containing clindamycin and benzoyl peroxide (BPO) 5% have been shown to be effective in treating acne. However, the 5% concentration of BPO combined with inactive ingredients, such as surfactants, preservatives, and alcohols in these formulations, may contribute to skin irritation and dryness. An optimized formulation of clindamycin phosphate (CDP) and BPO using a low concentration of BPO (CDP 1.2% and BPO 2.5% gel) was developed without the use of preservatives, surfactants, or alcohol. Results of clinical studies in more than 2800 participants with moderate to severe acne demonstrated that using a once-daily, CDP 1.2% and BPO 2.5% gel is effective in the treatment of inflammatory and noninflammatory lesions of acne and is very well tolerated.