Synthesis and Biological Evaluation of Naphthopyranopyrimidines Derivatives as Potential Antifungal and Antibacterial Activities

摘要

A new series of novel 8,10-dimethyl-12-aryl-12H-naphtho[1',2,5,6]pyrano[2,3-d]pyrimidine-9,11-diones derivatives synthesized from coupling (3CC) of aldehydes, β-naphthol and 1,3-dirnethylbarbiturie acid derivatives with using green condition through a simple, mild and efficient procedure utilizing cellulose sulfuric acid as a catalyst. Final compounds were evaluated for antibacterial and antifungal activity. Compounds 4a, 4d, 4h display high potent antifungal activity against Candida parapsilopsis, compound 4d show more potent activity (MIC 4.6 mg/mL) better than miconazole. While compound 4d most effective on bacterial against Micrococcus luteus, Staphylococcus aureus MTCC 96 and Staphylococcus aureus MTCC 2940 with (MIC 2.3 mg/mL).