Copper Complexes of Imidazole-2-carbaldehyde N(4)-Substituted Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

摘要

Imidazole-2-carbaldehyde N(4)-pyrrolidinyl, N(4)-piperidinyl, N(4)-morpholinyl and N(4)-piperazinyl thiosemicarbazones and their copper(II) complexes have been synthesized. The compounds were characterized by NMR, IR, UV-visible, ESR spectroscopy and ESI mass spectrometry. The stoichiometry, spectroscopic and mass spectrometry data indicates thiosemicarbazone coordination to Cu(II) in neutral form with NNS donors. The coordination spheres of the metal ion are completed by chlorine atoms in approximately square pyramidal geometry. The in vitro antimicrobial properties of the compounds in broth culture exhibited a moderate inhibitory effect on the microbial proliferation. Some copper(n) complexes exhibited a moderate inhibitory activity, better than that of the corresponding free thiosemicarbazone.