Efficient Synthesis of Quinolo-oxepanes Through [3+2] Cycloaddition Reaction of α,β-Unsaturated Ester with Unstabilized Azomethine Ylides

摘要

New functionalized quinolo-oxepane were achieved by intramolecular 1,3-dipolar cycloaddition reaction of α,β-unsaturated ester with unstabilized azomethine ylides derived from various a-amino acids with high stereo selectivity and good yields. These derivatives were synthesized via Wittig reaction under mild, neutral conditions in a short duration and consistently good yields. The structures of final compounds were characterized by spectral analysis.