Synthesis of Enantioenriched 5,6-Dihydrophenanthridine Derivatives through retro-Carbopalladation of Chiral o-Bromobenzylamines

摘要

Retro-carbopalladation of aldimines in the presence of a suitable -hydrogen atom has been observed in the Pd-catalyzed homocoupling reactions of o-bromobenzylamines, providing an expeditious synthetic route to 5,6-dihydrophenanthridine derivatives. Furthermore, a highly enantioselective synthesis of 6-aryl-substituted 5,6-dihydrophenanthridines was achieved in a one-pot manner by taking advantage of Rh and Pd catalysis.