Palladium-Catalyzed Oxidative Arylalkylation of Activated Alkenes: Dual C-H Bond Cleavage of an Arene and Acetonitrile

摘要

The oxidative difunctionalization of alkenes is a powerful strategy for the synthesis of various organic compounds. Recent studies have demonstrated that palladium-catalyzed oxidative transformations, such as aminooxygenation, dia-mination, and dioxygenation of alkenes, can be used efficiently to achieve bond formations at vicinal positions. However, palladium-catalyzed oxidative dicarbonation of alkenes is quite challenging.Oxidative cross-coupling of arenes and alkenes using palladium catalysts have been extensively explored. These reactions involve C—H bond functionalizations to yield the intermediate A, which usually undergoes β-hydride elimination to afford Heck-type products (Scheme 1).