Highly Regio-,Diastereo-,and Enantioselective [2+2+2] Cycloaddition of 1,6-Enynes with Electron-Deficient Ketones Catalyzed by a Cationic RhVH8-binap Complex

摘要

Transition-metal-catalyzed [2+2+2] cycloaddition reactions are efficient methods for the construction of six-membered carbocycles and heterocycles.For the synthesis of six-membered oxygen heterocycles,[2+2+2] cycloaddition reactions involving carbonyl compounds are potentially attractive.Catalytic [2+2+2] cycloaddition reactions of diynes with carbonyl compounds in the presence of various transition-metal complexes have been reported,for example,with Ni,Ru,and Rh.