Editorial Foeusi A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus oe: 'Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.'

摘要

the renin-angiotensin system (RAS) is well recognized as a critical regulator of blood pressure and a determinant of cardiovascular homeostasis. The RAS was originally described in the circulation, although the presence of many or all components of the RAS has been documented in a variety of individual tissues including kidney, brain, heart, adrenal gland, and blood vessels (4). The importance of these local versions of the RAS in the development and maintenance of hypertension and associated end-organ damage has been firmly established.