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首页> 外文期刊>American Journal of Physiology >Carotid baroreflex responsiveness is impaired in normotensive African American men.
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Carotid baroreflex responsiveness is impaired in normotensive African American men.

机译:血压正常的非裔美国人的颈动脉压力反射反应能力受损。

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There are important differences in autonomic function and cardiovascular responsiveness between African Americans (AA) and Caucasian Americans (CA). This study tested the hypothesis that carotid baroreflex (CBR) responsiveness is impaired in normotensive AA compared with normotensive CA at rest. CBR control of heart rate (HR) and mean arterial blood pressure (MAP) was assessed in 30 nonhypertensive male subjects (15 AA; 15 CA; age 18-33 yr) with 5-s periods of neck pressure (NP; simulated hypotension) and neck suction (NS; simulated hypertension) ranging from +45 to -80 Torr during rest. Carotid-cardiac stimulus-response curves revealed a significantly lower minimum HR response in the CA compared with AA (40.8 +/- 2.4 vs. 49.8 +/- 2.9 beats/min, respectively; P < 0.05). In addition, the magnitude of the mean HR response to all trials of NS (-20, -40, -60, and -80 Torr) was attenuated in the AA group (AA, -10.1 +/- 1.7 vs. CA, -14.9 +/- 2.2 beats/min; P < 0.05), while no significant differences were found in the magnitude of the mean HR response to NP (+15, +30, and +45 Torr) between racial groups. There were no significant differences in the carotid-vasomotor stimulus-response curves between racial groups. Also, while no racial differences were found in the magnitude of the mean MAP response to all trials of NS, the magnitude of the mean MAP response to all trials of NP was attenuated in the AA group (AA, 7.2 +/- 1.3 vs. CA, 9.3 +/- 1.1 mmHg; P < 0.05). Together, these findings support inherent differences in short-term blood pressure regulation between racial groups that exhibit different relative risk for the development of hypertension.
机译:非裔美国人(AA)和高加索裔美国人(CA)在自主神经功能和心血管反应方面存在重要差异。这项研究检验了以下假设:与正常血压静息CA相比,正常血压AA的颈动脉压力反射(CBR)反应性受损。在30名非高血压男性受试者(15 AA; 15 CA;年龄18-33岁)中,以5 s的颈部压力(NP;模拟低血压)评估了CBR对心率(HR)和平均动脉血压(MAP)的控制休息时,颈部和颈部吸引(NS;模拟高血压)的范围从+45到-80托。颈动脉的刺激反应曲线显示,与AA相比,CA的最低HR反应明显降低(分别为40.8 +/- 2.4 vs. 49.8 +/- 2.9次/ min; P <0.05)。此外,AA组减弱了所有NS试验(-20,-40,-60和-80 Torr)的平均HR反应幅度(AA,-10.1 +/- 1.7 vs. CA,- 14.9 +/- 2.2次/分钟; P <0.05),而种族之间对NP的平均HR反应幅度(+ 15,+ 30和+45 Torr)没有发现显着差异。种族之间的颈动脉血管舒缩刺激反应曲线没有显着差异。此外,虽然在所有NS试验中的平均MAP反应强度均未发现种族差异,但在AA组中,所有NP试验的平均MAP反应强度均较弱(AA,7.2±1.3 vs. CA,9.3 +/- 1.1 mmHg; P <0.05)。总之,这些发现支持了种族人群之间短期血压调节的内在差异,这些种族人群表现出不同的高血压发展相对风险。

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