COMPOSITIONS COMPRISING RARE GENETIC SEQUENCE VARIANTS ASSOCIATED WITH PULMONARY FUNCTION AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF ASTHMA IN AFRICAN AMERICAN PATIENTS

摘要

Compositions for the diagnosis and treatment of asthma are disclosed. In accordance with the present invention, a method for detecting, diagnosing and/or treating asthma in a human subject of African descent is provided. An exemplary method comprises detecting at least one single nucleotide polymorphism (SNP) listed in Table 1 or a SNP in linkage disequilibrium with one or more of the SNPs selected from rs2529168, rs2529136, rs2429063, rs2529155, 7:21303293, rs2700292, rs2700296, 7:21328865, rs10267234, and rs150512506 or a SNP in LD with any of said SNPs, in a nucleic acid sample from the subject, wherein detection is correlated with an increased risk, susceptibility, or predisposition to asthma.