Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

摘要

To date, experiments investigating the influence of altered circadian clock function in vivo have primarily involved manipulation of the light-dark cycle and/or genetic ablation of circadian clocks in a ubiquitous manner (24, 36). Experimental strategies using such global manipulations influence both central and peripheral circadian clocks within the organism, as well as virtually every neurohumoral factor investigated to date (24, 36, 40).