pifferential modulation of voltage-dependent K~+ currents in colonic smooth muscle by oxidants

摘要

The effect of oxidants on voltage-dependent K~+ currents was examined in mouse colonic smooth muscle cells. Exposure to either chloramine-T (Ch-T), an agent known to oxidize both cysteine and methionine residues, or the colon-specific oxidant monochloramine (NH2CI) completely suppressed the transient outward K~+ current (I_(to)) while simultaneously enhancing the sustained delayed rectifier K~+ current (I_(dr)).